Wednesday, July 3, 2013

Researching

I started my Inositol and Flaxseed, as you know. The powder isn't bad, it has a hint of sweetness; I don't even notice it in my lemonade. I still haven't decided out what dose I should take of either though.With the Flaxseed (1g) it says to take 2-3 times a day. I've settled with two a day, and hopefully that will be enough. The Inositol recommendations really vary though. The package says 1-3 times a day (1/4tsp = 1g). Online I see most people using 2g, but then some people say 4g (Pregnitude seems to use this amount). Right now I'm doing 2g a day, and I'm still on 2,000mg Metformin. While my RE had no hesitations about taking them together, and recommended Pregnitude (which would mean 4g a day), online some people say not to. I defer to my doctor, obviously, but I don't want to overdo it.

Oh the joys of debating against myself- an argument I never truly win!

I looked up studies on it, and there's been some interesting stuff since I got pregnant with V. Mind you, I took 2g a day back then hoping it would help egg quality. There weren't a lot of studies though, and even now there aren't what I would call a lot. I did see a few suggesting that it may improve egg quality in PCOS women though (here, and here). The first one showed an improvement in mature eggs and decrease in immature ones. It doesn't say how many were in the study, and I can't see the specifics, but it is interesting. The second study compares Inositol to D-Chiro-Inositol (which was the recommended form years ago) and their effects on oocyte/embryo quality; the study favors Inositol. The first study said the women took 2g a day for 3 months, so I think starting it now makes even more sense. I don't know how much it helped with the cycle I conceived V, but it's something I definitely want to try again in earnest.

Now if I could just decide on dose, ha! I think 2g for now is good, but I may increase it was we get closer to go time. I've been on it for a day or two now, and I haven't had any issues so far. Same with the flaxseed oil. If I'm lucky I'll see some results from all this, and if not, well at least I gave it a shot.

8 comments:

Jay said...

There is actually a study suggesting that the best combo is 1.1 g myo inositol and a little d- chiro inositol daily.
Can give you the link.

Inositol really may have improved my response... Most of my eggs were mature, nearly all of them fertilized.

Best of luck!

Rebecca said...

wishing i had known about this years ago. Hoping it does improve your chances.

AnotherDreamer said...

Jay, feel free to share the link! I don't think I'm going to add D-Chiro, but would love to see the study. I had some hesitations about it before due to cost and how it was derived (It may have been pine? which I'm allergic to).

iamstacey said...

Wow, that is a lot to figure out! You've really done your research. I never realized there were things I could've done to improve egg quality. I should've thought of it, as there were a lot of things the endocrinologist and urologist gave to Troy to improve sperm quality. And they worked!

Jay said...

The preparation is called "Inofolic combi." The study is: http://www.ncbi.nlm.nih.gov/pubmed/23708322

The real test would be to see how effective this combination is compared to myo-inositol alone. I'm starting to think that a lower dose (1000 mg/day as opposed to a 2000 mg twice a day) may be a good idea.

Tova said...

I just found your blog (based on your bloggess comment link) I hope it works out for you. I like your scientific approach.

AnotherDreamer said...

Thank you Tova. I am so sorry for your loss too.

Glass Case of Emotion said...

I have to look into this stuff... fingers crossed for you. Boo on PCOS.